OrthoDB: Database of Orthologous Groups



Copy-Number Searches
A) Select radiation node and define your copy-number profile on the tree above then


B) Choose from pre-defined profile


Sequence Search



















The Hierarchical Catalog of Orthologs

OrthoDB presents a catalog of orthologous protein-coding genes across 64 vertebrates, 57 arthropods, 175 fungi, 14 basal metazoans, and 1115 bacteria. Orthology refers to the last common ancestor of the species under consideration, and thus OrthoDB explicitly delineates orthologs at each radiation along the species phylogeny. The database of orthologs presents available protein descriptors, together with Gene Ontology and InterPro attributes, which serve to provide general descriptive annotations of the orthologous groups, and facilitate comprehensive orthology database querying.

View latest publication in NAR Waterhouse et al, 2013.

Search OrthoDB:   "Cytochrome P450"   protease | peptidase   kinase -serine   FBgn0036816   IPR017981   GO:0006950   "immune response"   "stress response"   "breast cancer"   diabetes

For detailed instructions on OrthoDB search functions, data sources, and further information, please see Help. Email support[at]orthodb.org for further help.

OrthoDB6 2012: 52 vertebrates, 45 arthropods, 142 fungi, 13 basal metazoans, & 1115 bacteria
OrthoDB5 2011: 48 vertebrates, 33 arthropods, 73 fungi, & 12 basal metazoans
OrthoDB4 2010: 44 vertebrates, 25 arthropods, 46 fungi, & 5 basal metazoans
OrthoDB3 2009: 40 vertebrates, 23 arthropods, & 32 fungi
OrthoDB2 2008: 15 vertebrates, 20 arthropods, & 23 fungi

Please Cite:
Waterhouse RM, Zdobnov EM, Tegenfeldt F, Li J, Kriventseva EV.
OrthoDB: a hierarchical catalog of animal, fungal and bacterial orthologs.
NAR, Jan 2013, PMID:23180791

Email: support[at]orthodb.org

OrthoDB-News Join the mailing list to keep abreast of the latest developments.
BUSCO Benchmarking sets of Universal Single-Copy Orthologs.
Downloads Protein sequences and orthologous group annotations for major clades.
Species List View all species in the current OrthoDB release.
Citation List View articles that cite OrthoDB.



Creative Commons Licence   This work by E Zdobnov lab is licensed under a Creative Commons Attribution 3.0 Unported License.